Neurodevelopmental disorders like autism very likely have their origin at the dawn of life, with the emergence of inappropriate connectivity between nerve cells in the brain. In one such disorder, Rett syndrome, the pathology is traceable to the failure of a specific gene, called MECP2. In mouse models of Rett syndrome -- which in humans is seen overwhelmingly in females -- the researchers have demonstrated how failure of Mecp2, the mouse equivalent of the human gene of the same name, has biological consequences that prevent adult females from learning how to gather newborn pups in the days immediately following the pups' birth. The team discovered that during the five days following the birth of pups, normal Mecp2 gene expression is required in order for adult females to learn how to gather wayward pups into a nest. Videos shown here compare the learned pup-retrieval behavior in healthy adult females with the inability of females with impaired Mecp2 expression to learn the task when placed in the same cage as a healthy mom. This inability to learn was traced by the team to a cascade of failures at the molecular level.
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ISBN 13: 9781158701063
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Aim: To know the the relationship between body weight and linear body measurements such as body length, height at withers and heart girth in Malabari adult female goats under field conditions. Materials and Methods: A total of adult female Malabari goats' body weight and body measurements body length, height at withers and heart girth were used to develop the step wise multiple regression equations. Results: The average body weight, body length, height at withers and heart girth were Prediction of body weight based on heart girth alone or combined with other body measurements had higher coefficient of determination R2 and lower residual mean square MSE. Conclusion: It could be concluded that the prediction model for body weight of Malabari female adult goats with independent variable heart girth can be better fit.
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